Understanding IgA nephropathy (Berger disease)

IgA nephropathy, also called Berger disease, is a kidney condition in which an immune protein called immunoglobulin A (IgA) builds up in the kidneys’ filters. Over time, this can cause blood or protein to appear in the urine and, for some people, reduce kidney function. It is not a liver disease, but it matters to The Liver Hope Foundation community because hepatitis, cirrhosis, and transplant-related health needs can overlap with kidney concerns. We provide plain-language education and support to help patients and caregivers prepare for conversations with their kidney, liver, or transplant-care teams. This page is educational and does not replace medical diagnosis or treatment.

Frequently asked questions

Getting a kidney diagnosis or an unexpected urine test result can feel overwhelming. These answers explain the basics of IgA nephropathy, what to monitor, and how to work with your care team—especially when liver disease or transplant care is also part of your health journey.

How does IgA nephropathy relate to liver disease or transplant care?

IgA nephropathy is primarily a kidney disease. However, hepatitis and cirrhosis are associated with a higher likelihood of IgA nephropathy, and people with advanced liver disease or transplant-related needs may require coordinated kidney and liver care. Make sure every member of your care team knows about your kidney, liver, and transplant history and all medicines you take.

What treatment or daily steps might be recommended?

Care is tailored to your kidney function, urine protein, blood pressure, overall health, and liver or transplant needs. Your clinical team may discuss blood pressure management, kidney-protective medicines, nutrition guidance, and other treatments when appropriate. Do not start, stop, or change medicines, supplements, or diets without checking with your clinical team.

What should I ask my kidney specialist?

Bring a written list of questions, such as: What are my urine protein and kidney function results? What is my blood pressure goal? How often do I need testing? Could my liver condition, transplant medicines, or other treatments affect my kidneys? Which symptoms should prompt me to call? A caregiver or trusted support person can help take notes and remember next steps.

When should I contact a clinician promptly?

Contact your clinician promptly for new or worsening swelling, much less urine than usual, visible blood in your urine, severe or persistent nausea or vomiting, shortness of breath, or concerning changes in how you feel. Seek emergency care or call 911 for severe trouble breathing, chest pain, fainting, confusion, or other life-threatening symptoms. Follow the emergency instructions provided by your own care team.

What is IgA nephropathy (Berger disease)?

IgA nephropathy is a disease that affects the kidneys’ tiny filtering units, called glomeruli. IgA, an antibody that helps the immune system, can collect in these filters and cause inflammation and damage. The condition can range from mild to more serious, and its course differs greatly from one person to another.

What do blood or protein in my urine mean?

Blood in the urine may make urine look pink, tea-colored, or cola-colored, though it can also be visible only on a lab test. Protein in the urine is often found through testing and can be a sign that the kidney filters are leaking. These findings need follow-up with a clinician, but they do not by themselves tell you exactly how quickly the condition will progress.

Will I lose kidney function?

Not everyone with IgA nephropathy develops kidney failure. Some people have stable disease for many years, while others have a higher risk of decline. Regular follow-up helps a kidney specialist track urine protein, kidney function, and blood pressure over time and create an individualized care plan.

How is IgA nephropathy diagnosed and monitored?

Clinicians may use urine tests, blood tests that measure kidney function, blood pressure checks, and other evaluations. A kidney biopsy is commonly used to confirm the diagnosis and assess kidney changes. Ask your kidney specialist which tests you need, what your results mean, and when they should be repeated.

You do not have to navigate kidney and liver concerns alone

The Liver Hope Foundation in Henderson, Nevada, offers education and caregiver support to help you prepare for productive conversations with the appropriate kidney, liver, or transplant-care team. Reach out for support, bring your questions, and stay connected to regular clinical follow-up.